Publications on
the Seraph 100
2025
- Harris, Keswani, Mottes, et. al. Seraph 100 Microbind Affinity Blood Filter for Persistent Pediatric BK Virus Nephropathy. Pediatric Transplantation Case Report 2025; 29 (3) doi.org/10.1111/petr.70055
- Waldron, Wang, Shishido, et al., Selective removal of proteins and microvesicles ex vivo from blood of pancreatic cancer patients using bioengineered adsorption filters. Cancer Letters, Volume 614, 2025, 217546, ISSN 0304-3835 doi 10.1016/j.canlet.2025.217546
- Masri, Moseley, Vaitkus, Seraph 100 Microbind Affinity Blood Filter and Use in Group A Streptococcus Sepsis: A Case Report. Critical Care Medicine, January 2025, 53 (1). doi:10.1097/01.ccm.0001105244.93350.89
2024
- Okioma R, Soki K et al. Successful Repeated Use of a Pathogen Adsorbing Biomimetic Device for the Adjunct Treatment of a SARS-CoV-2 Reinfection and Subsequent Infections with Different Multiresistant Bacteria. Case Rep Nephrol Dial (2024) 14 (1): 171–177. doi: 10.1159/000541422
- Shishido SN, Suresh D et al. Determining the efficacy of ExThera Seraph100 blood filtration in patients diagnosed with pancreatic cancer through the liquid biopsy. BJC Rep 2, 47 (2024). doi: 10.1038/s44276-024-00069-3
- De Rosa S, de Cal M, et al. Seraph® 100 affinity blood cartridge as a potential adjunctive blood purification strategy for S. aureus-induced septic shock, Nephrology Dialysis Transplantation, Volume 39, Issue Supplement_1, May 2024, gfae069–1175–557 #557, doi: 10.1093/ndt/gfae069.1175
- Schmieszek J, Fuehner T, et al. Effect of a biomimetic pathogen adsorbing device on inflammatory biomarkers in COVID-19 patients. Ther Apher Dial. 2024. doi: 10.1111/1744-9987.14137
- Lacquaniti A, Smeriglio A, et al. In Vitro Simulated Hemoperfusion on Seraph® – 100 as a Promising Strategy to Counteract Sepsis. Biomedicines. 2024; 12(3):575. doi: 10.3390/biomedicines12030575
- Seffer M-T, Meyer TM, et al. Using the Seraph® 100 Microbind® Affinity blood filter under slow flow conditions through 18 G and 16 G central lines. The Journal of Vascular Access. 2024;0(0). doi: 10.1177/11297298241234073
- DeLuca JP, Selig DJ, Vir P, et al. Seraph 100 Microbind Affinity Blood Filter does not clear antibiotics: an analysis of antibiotic concentration data from PURIFY-OBS. Eur PMC 2024 doi:10.1159/000531951
- Votrico V, Grilli M, Gerini U et al. Hemoperfusion with high-affinity polyethylene microbeads (Seraph-100®) for the removal of pathogens in chronic critically ill patients: Clinical experience. IJAO 2024; 47(2):115-117. doi: 10.1177/03913988231221405
2023
- Pavlov M, Poljak T, et al. Enterobacter cloacae septicemia in a triple-cannula extracorporeal membrane oxygenation circulatory support treated with Seraph-100 Microbind affinity blood filter, Croat Med J. 2023;64:284-8. doi: 10.3325/cmj.2023.64.284
- Li D, Burke T, Smith J, et al. Use of the Seraph® 100 Microbind® Affinity Blood Filter in an adolescent patient with disseminated adenoviral disease, Pediatric Nephrology, 2023; doi: 10.1007/s00467-023-06097-4
- Premuzic V, Situm I, Lovric D, et al. Sequential Extracorporeal Blood Purification Is Associated with Prolonged Survival among ICU Patients with COVID-19 and Confirmed Bacterial Superinfection, Blood Purification, 2023; doi: 10.1159/000531356
- Seffer M, Weinert M, Molinari G, et al. Staphylococcus aureus Binding to Seraph® 100 Microbind® Affinity Filter: Effects of Surface Protein Expression and Treatment Duration, PLOS One, 2023;18(3):1-14 doi: 10.1371/journal.pone.0283304
- Stoffel S, Boster J, Jarrett Z, et al. Single-Center Experience With the Seraph-100® Microbind® Affinity Blood Filter in Patients With SARS-CoV-2 Infection and Septic Shock at a Military Treatment Facility, Military Medicine, 2023;00(0/0):1:1-5 doi: 10.1093/milmed/usad063
- Merrill K, Krallman K, Loeb D, et al. First-Time Use of the Seraph® 100 Microbind® Affinity Blood Filter in an Adolescent Patient with Severe COVID-19 Disease: A Case Report. Nephrol Dial 2023;13:1-6. doi: 10.1159/000527290
2022
- Andermatt R, Bloemberg G, Ganter C, et al. Elimination of Herpes Simplex Virus-2 and Epstein-Barr Virus with Seraph 100 Microbind Affinity Blood Filter and Therapeutic Plasma Exchange: An Explorative Study in a Patient with Acute Liver Failure. Crit Care. 2022;4(8):0745. doi: 10.1097/CCE.0000000000000745
- Ebeyer-Masotta M, Eichhorn T, Weiss R, Lauková L, Weber V. Activated Platelets and Platelet-Derived Extracellular Vesicles Mediate COVID-19-Associated Immunothrombosis. Front Cell Dev Biol. 2022;10:914891. doi:10.3389/fcell.2022.914891
- Eden G, Schmidt J, Büttner S, et al. Safety and efficacy of the Seraph® 100 Microbind® Affinity Blood Filter to Remove Bacteria from the Blood Stream: Results of the First in Human Study. Crit Care. 26, 181 (2022). Doi:10.1186/s13054-022-04044-7
- Monard C, Abraham P, Schneider A, Rimmelé T. New Targets for Extracorporeal Blood Purification Therapies in Sepsis. Blood Purif. 2022. doi: 10.1159/000524973
- Miller MK, Spiller RE, Mount CA, Colombo C, Khayat MI. Novel Use of Seraph-100™ Blood Purification Therapy in Heat Stroke. Mil Med. 2022;usac124. doi:10.1093/milmed/usac124
- Ronco C, Bellomo R. Hemoperfusion: Technical Aspects and State of the Art. Crit Care. 2022;26(135). doi:10.1186/s13054-022-04009-w
- Lezhnina A, Lem V, Blatt N. Application of Extracorporeal Apheresis in Treatment of COVID-19: A Rapid Review. Bionanoscience. 2022;1-15. doi:10.1007/s12668-022-00987-x
- Selig DJ, Reed T, Chung KK, Kress AT, Stewart IJ, DeLuca JP. Hemoperfusion with Seraph 100 Microbind Affinity Blood Filter Unlikely to Require Increased Antibiotic Dosing: A Simulations Study Using a Pharmacokinetic/Pharmacodynamic Approach. Blood Purif. 2022;1-7. doi:10.1159/000524457
- Basel AP, Thomas J, Williams AM, et al. 709 Reconfiguration: Extracorporeal Blood Purification of a Burn Patient on ECMO. J Burn Care & Res. 2022; 43(1):160. doi: 10.1093/jbcr/irac012.263
- Ebeyer-Masotta M, Eichhorn T, Weiss R, et al. Heparin-Functionalized Adsorbents Eliminate Central Effectors of Immunothrombosis, Including Platelet Factor 4, High-Mobility Group Box 1 Protein and Histones. Int J Mol Sci. 2022;23(3):1823. doi:10.3390/ijms23031823
- Schmidt JJ, Borchina D, van’t Klooster M, et al. Interim Analysis of the COSA (COVID-19 Patients Treated with the Seraph 100 Microbind Affinity Filter) Registry. Nephrol Dial Transplant. 2022; 37(4):673-680. doi: 10.1093/ndt/gfab347
2021
- Rosas M, Niazi N, Kalra A, et al. Extracorporeal Blood Purification in COVID-19 with Seraph 100 Microaffinity Blood Filter: A Single-Center Case Series. Chest. 2021;160(4):A626-A627. doi:10.1016/j.chest.2021.07.599
- Barnett S, Sharma K. The Seraph Filter VS the Cytokine Storm. Chest. 2021;160(4):A1006. doi:10.1016/j.chest.2021.07.936
- Kelly MM, Wilkinson JD, Rastegar M, Lewis MS, Betancourt J. Two Patients with Severe COVID Pneumonia Treated with the Seraph-100 Microbind Affinity Blood Filter. J Intensive Care Med. 2021;36(10):1228-1232. doi:10.1177/08850666211039744
- Extracorporeal Blood Purification is Appropriate in Critically Ill Patients with COVID-19 and Multi-Organ Failure:
PRO: Chung K, Olson S. Extracorporeal Blood Purification Is Appropriate in Critically Ill Patients with COVID-19 and Multiorgan Failure: PRO. Kidney360 3(3):416-418. doi: 10.34067/KID.0006632020
CON: Kashani K, Forni L. Extracorporeal Blood Purification Is Appropriate in Critically Ill Patients with COVID-19 and Multiorgan Failure: CON. Kidney360 3(3):419-422. doi: 10.34067/KID.0007382020
COMMENTARY: Ostermann M, Koyner J. Extracorporeal Blood Purification Is Appropriate in Critically Ill Patients with COVID-19 and Multiorgan Failure: COMMENTARY. Kidney360 3(3):423-425. doi: 10.34067/KID.0005242021 - Schmidt JJ, Bode-Böger SM, Martens-Lobenhoffer J, Hoeper MM, Kielstein JT. Pharmacokinetics of Remdesivir and GS-441524 During PIRRT and Seraph 100 Therapy. Clin J Am Soc Nephrol. 2021;16(8):1256-1257. doi:10.2215/CJN.17601120
- Rifkin BS, Stewart IJ. Seraph-100 Hemoperfusion in SARS-CoV-2-Infected Patients Early in Critical Illness: A Case Series. Blood Purif. 2022;51(4):317-320. doi:10.1159/000517430
- Chen L, Kraft BD, Roggli VL, et al. Heparin-Based Blood Purification Attenuates Organ Injury in Baboons with Streptococcus Pneumoniae Pneumonia. Am J Physiol Lung Cell Mol Physiol. 2021;321(2):L321-L335. doi:10.1152/ajplung.00337.2020
- Kielstein JT, Borchina D, Fuhner T, et al. Hemofiltration with the Seraph® 100 Microbind® Affinity Filter Decreases SARS-CoV-2 Nucleocapsid Protein in Critically Ill COVID-19 Patients. Crit Care. 2021; 25:190. doi: 10.1186/s13054-021-03597-3
- Chitty S., et al. A Multicenter Evaluation of Blood Purification with Seraph 100 Microbind Affinity Blood Filter for the Treatment of Severe COVID-19: A Preliminary Report doi: 10.1097/cce.0000000000000662
- Pape A, Kielstein JT, Krüger T, Fühner T, Brunkhorst R. Treatment of a Critically Ill COVID-19 Patient with the Seraph 100 Microbind Affinity Filter. TH Open. 2021;5(2):e134-e138. doi:10.1055/s-0041-1727121
- Schmidt J., et al. First Results of the COVID-19 Patients Treated with the Seraph® 100 Microbind® Affinity Filter (COSA) Registry NDT. 2021,May; 36(Suppl 1); gfab347doi: 10.1093/ndt/gfab099.0014
2020
2010 – 2019
- LaRosa S, McCrea K, Ward R. Removal of Cytomegalovirus from Blood by Heparin-Functional Hemoperfusion Media. Crit Care Med. 2014; 42 (12):A1597.
- (2014) Ebola-Fighting Technologies Come to the Fore
- LaRosa SP, Opal SM. Immune Aspects of Sepsis and Hope for New Therapeutics. Curr Infect Dis Rep. 2012;14(5):474-483. doi:10.1007/s11908-012-0276-2
Related Publications
- Mellhammar L, Kahn F, Whitlow C, et al. Bacteremic Sepsis Leads to Higher Mortality when Adjusting for Confounders with Propensity Score Matching. Sci Rep. 2021;11(6972). doi:10.1038/s41598-021-86346-4
- Clausen TM, Sandoval DR, Spliid CB, et al. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. Cell. 2020;183(4):1043-1057.e15. doi:10.1016/j.cell.2020.09.033
- Bermejo-Martin JF, González-Rivera M, Almansa R, et al. Viral RNA Load in Plasma is Associated with Critical Illness and a Dysregulated Host Response in COVID-19. Crit Care. 2020;24(1):691. doi:10.1186/s13054-020-03398-0
- Eichhorn T, Linsberger I, Lauková, L, et al. Analysis of Inflammatory Mediator Profiles in Sepsis Patients Reveals That Extracellular Histones are Strongly Eevated in Nonsurvivors. Mediators of inflammation. 2021;17. doi: 10.1155/2021/8395048
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